Furosemide Injection T P Drug Interactions

When a cardiac glycoside is administered concurrently, it should be remembered that potassium deficiency increases the sensitivity of the myocardium to digitalis. In case of concomitant glucocorticoid medication or abuse of laxatives, the risk of increased potassium loss should be borne in mind.
Furosemide may potentiate the nephrotoxic effects of certain antibiotics (e.g. aminoglycosides). Therefore, furosemide should be used with caution in patients with antibiotic-induced renal impairment. It should be borne in mind that the ototoxicity of aminoglycoside antibiotics (e.g. kanamycin, gentamicin, tobramycin) may be potentiated when furosemide is used concurrently. The hearing defects that result may be irreversible. Therefore, this drug combination should be restricted to vital indications. As the concomitant administration of cisplatin carries the risk of inducing hearing defects, the 2 drugs should not be used simultaneously.
Furosemide sometimes diminishes the potency of the other drugs (e.g. the effect of antidiabetics and pressor amines) or potentiates their effect (e.g. in the case of salicylates, theophylline, lithium and curarimimetic muscle relaxants). The action of other hypotensive drugs may be potentiated by furosemide. Especially in combination with ACE inhibitors, a marked fall in blood pressure may be seen.
Nonsteroidal anti-inflammatory agents (e.g. indomethacin) may antagonise the action of furosemide and may cause renal failure in case of preexisting hypovolemia.